New application deadline:
October 5th, 2012 - 12 noon (GMT).
An exclusive three day conference featuring keynotes by 15 of the world’s top scientists within protein research. Topics include: autophagy, DNA damage signaling, signaling systems and networks, metabolism and aging, cell cycle as well as epigenetics and cancer signaling.
- Tony Pawson (Mount Sinai Hospital, Canada)
- Ivan Dikic (Goethe University/FMLS, Germany)
- Steve Jackson (Gurdon Institute, United States)
- Jiri Lukas (NNF Center for Protein Research, Denmark)
- Andre Nussenzweig (National Cancer Institute, United States)
- Philippe Bastiaens (Max Planck Institute of Molecular Physiology, Germany)
- Forest White (Massachusetts Institute of Technology, United States)
- Matthias Mann (Max Planck Institute of Biochemistry, Germany)
- Eric Verdin (University of California San Francisco, United States)
- Søren Brunak (NNF Center for Protein Research, Denmark)
- Brenda Schulman (St. Jude Children's Research Hospital, United States)
- Gerald W. Hart (Johns Hopkins University, United States)
- Michael B. Yaffe (Massachusetts Institute of Technology, United States)
- Henrik Semb (DanStem, Denmark)
- Tim Hunt (Cancer Research UK, United Kingdom)
- Angus Lamond (The College of Life Science, University of Dundee, Scotland)
Post-translational modifications (PTMs) in cell signaling have evolved as the eukaryotic cell’s most important regulatory mechanism to regulate intracellular protein networks in response to external or internal cues. Site-specific modification of proteins by PTMs such as phosphorylation, ubiquitylation, and acetylation are involved in virtually all signaling pathways that orchestrate fundamental cellular processes including cell cycle progression, apoptosis, the DNA damage response, autophagy, and metabolism. Deregulation of proteins involved in these important cellular responses can often lead to disease, and the enzymes catalyzing addition or removal of PTMs have therefore emerged as prominent therapeutic targets. The meeting will focus on the cellular regulation of these fundamental processes by bringing together world leading researchers in the area of PTM functions in different cell signaling networks.